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1ah (vehicle (isotonic saline), n = 10 mice, 100 nmol kg 1 MK-801 n = 10 mice, 100 nmol kg 1 GLP-1 n = 10 mice, 100 nmol kg 1 GLP-1MK-801 n = 10 mice)

Colon-specific microspheres loaded with puerarin reduce tumourigenesis and metastasis in colitis-associated colorectal cancer

Efficacy in Diabetic Neuropathy: Systematic reviews demonstrate that ALC significantly reduces pain in diabetic peripheral neuropathy and enhances nerve conduction, suggesting its utility in nerve repair and pain relief (Veronese et al., 2017)

The STEP trials for semaglutide 2.4 mg (Wegovy) showed: Average weight loss of approximately 15% of body weight over 68 weeks One-third of participants lost 20% or more of body weight Significant reductions in waist circumference, blood pressure, and cardiovascular risk markers The SURMOUNT trials for tirzepatide (Zepbound) showed even more impressive results: Average weight loss of 20-25% at the highest dose (15 mg) over 72 weeks More than half of participants lost 20% or more of body weight Significant improvements in type 2 diabetes markers, blood pressure, and lipid profiles The head-to-head comparison is clear